Protein Bioinformatics & Computational Biology

Our group works on two complementary topics. First, we develop computational methods for  predicting the structure, function, and evolution of proteins. This involves improving sequence search and alignment methods to make use of the vast amount of sequence information that is becoming available at an ever-increasing pace. Second, we want to understand how transcriptional regulation, which represents the most important level of cellular regulation, is encoded in each genes regulatory regions. We develop computational methods to predict transcriptional output, using quantitative modeling and statistical machine learning techniques.